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@# To investigate the clinical therapeutic effect of extracorporeal shock wave therapy in the treatment of cubital tunnel syndrome. Methods: Seven patients (10 elbows) with moderate cubital tunnel syndrome participated in this study. Three sessions of radial extracorporeal shock wave therapy (2,000 shots, 4 Bar, 5 Hz) (once a week) were administered to the ulnar nerve at the proximal cubital tunnel region. The primary and secondary outcomes were assessed using the Visual Analog Scale (VAS) and the shortened Disabilities of the Arm, Shoulder and Hand questionnaire (Quick DASH), respectively, at the 4th, 8th, and 12th week, following the 3rd session of shock wave therapy. Results: The VAS and Quick DASH scores demonstrated improvements at all follow-up time points, in all treated elbows. The mean VAS and Quick DASH score improved from 4.7±0.3(mean±SE) to2.2±0.2 and 16.6±2.1to 6.8±1.6 respectively during 12 weeks follow up (all p <0.01). Conclusion: This pilot study revealed the safety and efficacy of extracorporeal shock wave therapy in patients with moderate cubital tunnel syndrome.
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Objective To investigate the clinical value , the motive regularity, the temporal and spatial correlation between myocardium and adjacent pericardium of left ventricular short -axis in normal adsults by using dual pulse wave Doppler echocardiography .Methods Tissue dual pulse spectral Doppler images about segmental myocardium and adjacent pericardial of three complete cardiac cycles in 99 normal adults were collected synchronously by using dual pulse wave Doppler techenology ,6 segments were enrolled in this study, including the anterior and posterior wall at mitral valve , papillary muscles, and apex level of left ventricular short-axis view.The motive regularity of myocardium and adjacent pericardium at different levels and segments were observed .Peak speed, onset time and peak time between myocardium and adjacent pericardium in anterior and posterior wall of three valves were measured online in systolic , early diastolic, and late diastolic, and the correlation between segmental myocardium and adjacent pericardium in speed and time were analyzed.Results Dual pulse wave Doppler echocardiography showed that in left ventricular short-axis view, motion between myocardium and adjacent pericardium in the same segment had consistent direction, motions between myocardium and adjacent pericardium in anterior and posterior wall at the same level had opposite directions .Comparison of peak velocity, in anterior wall, the peak velocities of myocardium in systolic and late diastolic at mitral valve level , and the peak velocity of myocardium in systolic at papillary muscle level were lower than that of adjacent pericardium .In posterior wall, the peak velocities of myocardium in early diastolic and late diastolic at mitral valve level , the peak velocities of myocardium in systolic and early diastolic at papillary muscle level , and the peak velocity of myocardium in early diastolic at apex level were higher than that of adjacent pericardium , with statistical significance (t=-4.207, -2.078, 4.575, -2.277, -2.440, -2.292, 5.980, 2.604, all P<0.05).Comparison of onset time, the onset time of myocardium in systolic at papillary muscle level in anterior wall , and the onset time of myocardium in early diastolic at mitral valve level in posterior wall were lower than that of adjacent pericardium, with statistical significance (t =-2.447, -2.020, both P<0.05).Comparison of peak time, except the peak time of myocardium in systolic and early diastolic at mitral valve level in posterior wall was lower than that of adjacent pericardium , the remaining differences were statistically significant ( t =-3.530, -2.411, both P<0.05).Peak velocity, onset times and peak times of each segment measured between myocardium and adjacent pericardium were well correlated (r =0.407 -0.933, all P <0.01). Conclusions Dual pulse wave Doppler echocardiography can provide relativity and accordance between motive velocity and direction of left ventricular myocardium and adjacent pericardium in normal adults .It is a promising new method for the clinical diagnosis of constrictive pericarditis and differentiation with restrictive cardiomyopathy.
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OBJECTIVE: To study the chemical constituents in the leaves of Toona sinensis Roemor. METHODS: Silica gel column chromatography and preparative high performance liquid chromatography were used to isolate constituents from dichloromethane and ethyl acetate portion of ethanol extract of this Chinese medicine. Subsequently, the chemical structures were elucidated by NMR spectral data and physical and chemical properties. RESULTS: Eight compounds are isolated and elucidated as scopoletin(I), 4, 7-dimethoxy-5-methylcoumarin (II), (+)-catechin(III), quercetin-3-O-α-L-rhamopyranoside(IV), kaempferol-3-O-α-L-rhamopyrano-side(V), l, 2, 3, 4, 6-penta-O-galloyl-β-D-glucopyranose(VI), astragalin (VII) and ethyl gallate(VIII). CONCLUSION: Except for compounds IV, VI-VIII, the other four compounds are isolated from Toona sinensis Roemor for the first time, and compound V is for the first time isolated from Toona genus. Copyright 2013 by the Chinese Pharmaceutical Association.
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Objective: To study the clinical features and prognostic factors of bone metastases of non-small-cell lung cancer. Methods: The clinical data of 174 patients with bone metastases of non-small-cell lung cancer, who were treated in our hospital during April 1999 to June 2006, were retrospectively analyzed. Kaplan-Meier analysis was used to estimate the 1- and 2-year survival rates of patients. Log-rank test was used to screen the factors influencing the survival of patients and Cox regression was used to further confirm the independent factors. Results, The predilection sites of bone metastases of non-small-cell lung cancer were chest (38.1%), spine (32.8%), pelvis (16.3%), extremities (8.7%), and skull (4.1%), with the ribs (30.7%), lumber vertebrae (17.3%), and thoracic vertebra (13.1%) ranking the top three. The median survival time of the 174 patients was 10.73 months; Kaplan-Meier analysis showed that the 1- and 2-year survival rates were 47.1% and 17.8%, respectively. It was also showed that the PS Score, bone pain, asymptomatic bone metastases, solitary bone metastasis, serum AKP, LDH, and CEA were associated with the prognosis of patients (P<0.05). Multivariate analysis showed that PS score, solitary bone metastasis and single bone metastasis were the independent factors of prognosis. Conclusion: The predilection sites of bone metastasis of non-small-cell lung cancer include chest part (ribs), spine (lumber/thoracic vertebrae), pelvis (ilium), etc. PS score, asymptomatic bone metastases, and solitary bone metastasis have great influence on the prognoses of patients.